April 15-17, 2018
Conference Introduction & Reception: Gordon Mitchell & Dean Michael Perri
Session I: Therapeutic Intermittent Hypoxia
Moderators: Emily Fox (University of Florida) & Rachel Cowan (University of Miami)
- Gordon Mitchell (UF): Therapeutic potential of intermittent hypoxia: why are we here?
- Randy Trumbower (Spaulding Hospital/Harvard Medical School):Daily acute intermittent hypoxia to improve walking ability in persons with incomplete spinal cord injury.
- Milap Sandhu (Shirley Ryan Ability Lab, Chicago): Facilitation of motor function and factors restricting AIH-induced plasticity in humans.
- Gillian Muir (University of Saskatchewan): Effects of long term AIH on forelimb motor function in a rat model of cervical spinal injury.
- Monica Perez (University of Miami): AIH and corticospinal synaptic plasticity in humans.
Session II: Intermittent Hypoxia Gone Wrong (sleep apnea)
Moderators: Jane Butler (NeuRA, Sydney) & Barbara Smith (UF)
- Safwan Badr (Wayne State University, Detroit): Sleep-disordered breathing in patients with SCI: A perfect storm or a perfect opportunity?
- Julie Di Fiore (Case Western Reserve University, Cleveland):Patterns of IH in preterm infants during early postnatal life
- Ken OHalloran (University College Cork, Ireland): The ups and downs of intermittent hypoxia and respiratory muscle function
- Jason Mateika (Wayne State University, Detroit): Intermittent hypoxia-initiated plasticity in humans: A multipronged therapeutic approach to treat sleep apnea and overlapping co-morbidities.
- Zixi Cheng (University of Central Florida, Orlando): Chronic intermittent hypoxia: functional/anatomical plasticity in cardiac vagal axis?
Session III: PI Blitz (emerging ideas & new projects)
Moderators: Erica Dale (UF) & Danny Martin (UF)
- Janet Taylor (NeuRA, Sydney): AIH: plans and pitfalls
- Tanja Taivassalo (UF): IH in healthy aging: potential impact on mobility and muscle function.
- Barbara Smith (UF): Acute intermittent hypoxia in patients with amyotrophic lateral sclerosis
- Sophie Lalande (University of Texas, Austin): Intermittent hypoxia as a means to improve aerobic capacity in type 2 diabetes.
- Fernando Pena Ortega (Universidad Nacional Autonoma de Mexico, Mexico City): Chronic intermittent hypoxia affects odor habituation and discrimination
- Josh Yarrow (VA, Gainesville): Does intermittent hypoxia influence bone loss after spinal cord injury?
- Emily Fox (UF): Promoting trunk and respiratory function after SCI
- Laura McPherson (Florida International University, Miami): How does voluntary neural drive to motor units change after acute intermittent hypoxia?
- James Bilzon (University of Bath, UK): Therapeutic effects of resistance training with blood flow restriction in persons with physical disabilities
- Mark Bishop (UF): Sensory FLO
Session V: Mechanisms of Intermittent Hypoxia-Induced Respiratory Plasticity
Moderators: Laura McPherson (Florida International) & Martin Oudega (University of Miami)
- David Fuller (UF): Pharmacological modulation of AIH-induced respiratory motor plasticity.
- Warren Alilain (University of Kentucky, Lexington): The brake and accelerator towards respiratory motor recovery after cervical SCI.
- Michael Lane (Drexel University, Philadelphia): Spinal interneurons and phrenic plasticity after cervical spinal cord injury.
- Valerie Verge & Joelle Nadeau (University of Saskatchewan, Canada): Acute intermittent hypoxia as a strategy to promote peripheral nerve repair.
Session IV: Trainee Blitz
Moderators: Bernard Conway (Strathclyde) & Fernando Pena Ortega (Mexico City)
- Breanna Arnold (University of Saskatchewan, Canada): The effects of AIH on expression of inflammatory markers in a rat model of cervical spinal injury.
- Austin Hocker (University of Oregon): Neonatal inflammation undermines adult respiratory plasticity.
- Arash Tadjalli (UF): Inflammation and phrenic motor plasticity: mechanisms of impairment.
- Behzad Toosi (University of Saskatchewan, Canada): AIH-induced expression of plasticity-related proteins in a rat model of cervical spinal injury.
Session VI: Therapeutic Potential of Intermittent Hypoxia
Moderators: Simon Gandevia (NeuRA, Sydney) & Gail Forrest (Kessler Foundation)
- Zev Rymer (Shirley Ryan Ability Lab): How do we get from here (research) to there (clinical practice)?
- Neil Euliano (Convergent Engineering): Practicalities of device design for in-clinic and in-home use.
- Samuel ShangwuWu (UF): Introduction to adaptive clinical trial designs: strengths and weaknesses.
- Tatiana Serebrovskaya (Bogomoletz Institute of Physiology, Kiev, Ukraine): Individual features of adaptation to intermitent hypoxia: the role of the dose in adaptive/disadaptive responses.
- Elisa Gonzalez-Rothi (UF): Therapeutic potential of intermittent hypoxia: dose effects.
Session VII: Trainee Blitz
Moderators: Ianessa Humbert (UF) & Mark Bishop (UF)
- David Burns (University College Cork, Ireland): Intermittent hypoxia in neuromuscular disease: pathological feature or potential therapy?
- Agioula Toli (University of Strathclyde, Glasgow): The influence of intermittent hypoxia training on motor performance in healthy subjects and patients with incomplete spinal cord injury.
- Seung Jae Kim (Heart Research Institute, Sydney): Carotid body and subfornical organ AT1R-mediated sympathoexcitation following repetitive hypoxia requires intrarenal ischemia in rats.
- Margo Randelmann (Drexel University, Philadelphia): Daily acute intermittent hypercapnia training to improve respiratory plasticity following spinal cord injury.
- Lana Zholudeva (Drexel University, Philadelphia): Intermittent hypoxia enhances connectivity between neuronal progenitors and injured cervical spinal cord.
- Lydia Hager (University of Kentucky): The ApoE4 gene as a barrier to respiratory motor plasticity.
- Latoya Allen (UF): Plasticity in respiratory spinal circuitry: impact of cervical spinal cord injury.
- Kristi Streeter (UF): ‘Intermittent hypoxia induces plasticity in cervical spinal interneurons.
- Shakeel Ahmed (UF): Acute intermittent hypoxia and inspiratory threshold loading as strategies to enhance inspiratory muscle function.
- Tommy Sutor (UF): Effects of therapeutic hypoxia on respiratory and trunk function in humans with SCI.
- Danielle McIntosh (University of Minnesota): Ventilatory long-term facilitation across the estrus cycle.
- Sébastien Baillieul: HypoxHeart (Joseph Fourier University, Saint-Martin-d’Heres, France): Contribution of hypoxic conditioning associated with exercise training in heart failure: experimental protocol and objectives of this randomised controlled double-blind trial.
- Raphael Perim (UF): Cellular interactions between distinct mechanisms of phrenic motor plasticity.
- Daryl Fields (University of Wisconsin): Respiratory plasticity: learning by failure.
Session VIII: Intermittent Hypoxia & Diverse Physiological Systems
Moderators: Tanja Taivassalo (UF) & Kristi Streeter (UF)
- Samuel Verges (Joseph Fourier University, Saint-Martin-d’Heres, France): Hypoxic conditioning in obese individuals.
- Zoya Serebrovskaya (Bogomoletz Institute of Physiology, Kiev, Ukraine): Intermittent hypoxia remedies male subfertility in humans.
- Melissa Farnham (Heart Research Institute, Sydney): The role of PACAP in intermittent hypoxia-induced sympathoexcitation.
Group Discussion: What have we heard and what next steps are needed to explore the biological and clinical significance of “low dose” therapeutic intermittent hypoxia?
Moderators: Elisa Gonzalez Rothi, Erica Dale, Randy Trumbower & Ken OHalloran