Neurotherapeutic Intermittent Hypoxia Workshop

The University of Florida Center for Respiratory Research and Rehabilitation presents:

Neurotherapeutic Intermittent Hypoxia Workshop

February 9-12, 2020

One Ocean Resort & Spa

Atlantic Beach, Florida

Group photo of 2018 Intermittent Hypoxia Retreat

2018 Intermittent Hypoxia Retreat

This year we invite PIs and trainees interested in neurotherapeutic applications of intermittent hypoxia to a workshop where we will review progress since the last workshop, establish future research priorities and recommend “next steps” for clinical translation.

The initial workshop was held at this same venue in July, 2016; one product of that workshop was a document entitled: “A ‘Road Map’ to clinical translation: Therapeutic intermittent hypoxia and recovery of motor function with chronic incomplete SCI.” Since then, considerable progress has been made, and it is time to consider the impact of new developments in the field.

A major goal will be to create an updated and expanded “Road Map” that considers potential neurotherapeutic applications beyond SCI. I have arranged to publish a special edition on the topic of this workshop in Experimental Neurology.

Topics will range from basic science (cellular/network mechanisms) and translational studies in animal models or humans, to funded clinical trials. In the workshop, we restrict attention to potential neurotherapeutic applications. Likely topics concern intermittent hypoxia effects on diverse motor (walking, hand/arm, swallowing, breathing), sensory, autonomic and cognitive functions. Other topics may relate to device design and/or translational barriers.

If you are interested in attending, please email Dr. Mitchell.


Agenda

A few speakers have been invited because of their active involvement in the Therapeutic Intermittent Hypoxia Consortium. However, other scientific program elements will be driven by attendance. We propose full length talks (20-25 minutes plus five minutes for discussion), a data blitz (three to five minute talks) and time for breakout discussions concerning future research priorities.

We hope that talks will be interactive and candid, presenting new findings, preliminary reports on ongoing studies, discussion of problems encountered and updates for ongoing clinical trials. Expected topics include:

  • Introduction: a review of the 2016 “Road Map” and its goals.
  • Funded human clinical trials on AIH and spinal cord injury (arm, leg, breathing)
  • Nontraditional clinical trial design (adaptive clinical trials)
  • Potential applications to other neurological disorders (ALS, MS, pain, stroke, cognitive impairment)
  • New insights concerning IH-induced plasticity mechanisms and factors undermining its efficacy
  • Updates on other topics including: biomarkers, device design and other.

Schedule of Events

Sunday, February 9:

  • Arrival and reception at 6 p.m.

Monday, February 10:

  • Breakfast at 8 a.m.
  • Morning session at 9 a.m. — Introduction and talks
  • Lunch at noon
  • Afternoon session at 1 p.m. — Talks
  • Dinner at 6:30 p.m.

Tuesday, February 11:

  • Breakfast at 8 a.m.
  • Morning session at 9 a.m. — Talks
  • Lunch at 11:45 a.m.
  • Afternoon sessions from 12:45 – 4:30 p.m. — Breakout discussions

Wednesday, February 12:

  • Breakfast at 7:30 a.m.
  • Morning session at 8:30 a.m. — Group discussion of research priorities and closing talk
  • Depart at noon