- NIH R01 HL147554-A0 (PI: G. Mitchell). “Optimizing respiratory plasticity with chronic cervical SCI.”.
- Major Goals: understand mechanisms limiting rAIH efficacy in rats with chronic cervical spinal cord injuries. Increased understanding will inform our efforts to optimize rAIH protocols for use in planned clinical trials in people suffering from impaired breathing due to chronic cervical spinal injury.
- NIH R01 HL148030-A0 (PI: G. Mitchell). “Regulation of intermittent hypoxia-induced respiratory motor plasticity.”
- Major Goals: intra-cellular mechanisms of acute intermittent hypoxia induced phrenic motor plasticity, including mechanisms enhancing phrenic long-term facilitation after repetitive AIH preconditioning, and the impact of age and sex on these mechanisms in rats.
- NIH R01 HL149800-A0 (PI: G. Mitchell). “Microglial regulation of intermittent hypoxia-induced phrenic motor plasticity.”
- Major Goals: inter-cellular mechanisms whereby microglia regulate serotonin- and adenosine-dependent forms of phrenic motor plasticity elicited by acute intermittent hypoxia in rats.
- NINDS R21 NS119862-01 (Co-I; PI: Y. Seven). “Nanoparticle-Based Drug Delivery Targeting the Respiratory Neural Network.”
- Major Goals: develop nanoparticle (carbon-dot) technologies to deliver cargo (drugs, fluorophores, toxins) across the blood brain barrier to the phrenic motor circuit.
- DoD SCIRP, Clinical Trial Award. (PD/PI: E. Fox; co-PI G.S. Mitchell). “Combined intermittent hypoxia and respiratory strength training to improve breathing function after SCI.”
- Major Goals: test the hypothesis that combined acute intermittent hypoxia and respiratory strength training will elicit great and more sustained gains in respiratory function than either treatment alone in people with chronic spinal cord injury.
- DoD CDMRP, Spinal cord injury expansion award (PD/PI: E. Fox; co-PI G.S. Mitchell). “Genetic biomarkers of intermittent hypoxia-induced respiratory motor plasticity in chronic SCI.”
- Major Goals: determine genetic biomarkers in saliva as a predictor of acute intermittent hypercapnic hypoxia-induced long term facilitation in people with chronic spinal cord injury and uninjured controls.
- ALSA Clinical Trial Award (PD/PI: B. Smith; co-I G.S. Mitchell). “Acute adenosine receptor antagonism to promote breathing plasticity in ALS.”
- Major Goals: test the hypothesis that pretreatment with an adenosine 2A receptor inhibitor enhances respiratory motor plasticity elicited by acute intermittent hypoxia in people with ALS.