BREATHE Research understanding & treating neuromuscular disorders that compromise respiratory and non-respiratory function

With investigators in over 20 departments and interests in preclinical, clinical, and translational research, the BREATHE Research Cores provide a nexus for interdisciplinary collaborations.

Research Cores

Airway Defense Core

Fundamental principles through clinical translation concerning mechanisms of swallowing disorders and cough, and changes in neuromuscular disease or injury.

airway clearance

Basic Breathing Research Core

Fundamental principles in the neural control of breathing and respiratory muscles are explored. Major areas of strength include: respiratory motor plasticity, opioid induced respiratory depression and muscle wasting with neuromuscular injury/disease, aging, heart failure, sepsis and cancer.

plasticity

Neurological Disorders Core

Major strengths include respiratory function in neuromuscular disorders (Spinal Cord Injury, Pompe Disease, Duchenne Muscular Dystrophy and ALS), neurodegenerative diseases (Parkinson’s disease, Alzheimer’s disease), and other clinical disorders (cancer cachexia, heart failure, sleep apnea).

neurological disorders

Neurotechnology Core

UF is developing strength in medical approaches to treat clinical disorders with electrical stimulation of relevant neural structures.

acellular tissue grafts

Neurotherapeutic Oxygen Core

UF is a center of research for this novel approach to therapeutics, including therapeutic intermittent hypoxia and hyperbaric oxygenation.

IH

Recruiting Patients

Current Clinical Trials

BREATHE Members run a variety of clinical trials focused on respiratory research and rehabilitation.

IH trial