Barry Byrne, MD, PhD

Barry Byrne, MD, PhD
Director of UF Powell Gene Therapy Center
Professor for Pediatrics and Molecular Genetics & Microbiology
Associate Chair for Pediatrics
Department of Pediatrics
College of Medicine

Research InterestsCenter for Respiratory Research and Rehabilitation
Dr. Byrne’s research is aimed at understanding types of inherited muscle disease, which lead to heart and skeletal muscle dysfunction. As a clinician scientist, he is studying a variety of rare diseases with specific attention to developing therapies for inherited muscle disease. As a pediatric cardiologist, his focus is on conditions that lead to skeletal muscle weakness and problems in heart and respiratory function. Current research focus is aimed to help those affected by Pompe Disease, an autosomal recessive lysosomal storage disease, and Barth Syndrome, an chromosomal X-linked defect.

Byrne and colleagues are taking two approaches to the problem. The first approach is vector replacement using rAAV, a recombinant virus vector constructed from adeno associated virus (AAV). Second, the Byrne lab is using protein-replacement therapy in an effort to treat deficiencies caused by genetic disorders with specific supplementation.

Degrees and Training

  • BS, Denison University
  • MD and PhD, University of Illinois
  • Pediatrics residency, cardiology fellowship training and post-doctoral training in Biological Chemistry, Johns Hopkins Hospital