BREATHE Research understanding & treating neuromuscular disorders that compromise respiratory and non-respiratory function

With active members in 17 departments and interests in preclinical, clinical, and translational research, the UF BREATHE Center Research Cores provide a nexus for interdisciplinary collaborations.

Research Cores

Control of Breathing & Airway Defense Core

The UF BREATHE Center explores key principles in the neural control of breathing and respiratory muscle activity, as well as clinical applications related to breathing, swallowing or cough impairment. Major areas of emphasis include fundamental studies of respiratory neuroplasticity, respiratory muscle function, neural control of the lung airways and vasculature, and opioid-induced respiratory depression. We apply new knowledge to improve function in cases of neuromuscular diseases such as ALS, Pompe and Parkinson’s disease, aging, heart failure, stroke, sepsis and cancer and traumatic brain and spinal cord injury.

airway clearance

Spinal Cord Injury Core

The UF BREATHE Center is devoted to developing new therapeutics that preserve or restore breathing and airway defense, walking, hand/arm function and overall health for those living with spinal cord injuries. With acute injuries, we are actively exploring oxygen therapeutics in the intensive care unit to preserve spinal cord tissue and optimize functional outcomes. With chronic injuries, we harness the capacity for spinal cord plasticity by applying therapeutic acute intermittent hypoxia, spinal electrical stimulation, respiratory strength training, and drug treatments. Many investigations use treatment combinations to optimize outcomes.

spinal cord

Recruiting Patients

Current Clinical Trials

BREATHE members run a variety of clinical trials focused on respiratory research and rehabilitation.

IH trial